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Another NAM analog-based NNMT inhibitor, 6-methoxy NAM (also known as JBSNF000088), has shown promise in decreasing body weight and enhancing insulin sensitivity in mice models of obesity induced by a high-fat diet 198

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Their byproducts promote endothelial dysfunction and accelerate the atherosclerotic process (129131)

Research protocols typically cite a range of 250-500 mcg per day administered subcutaneously in a fasted state, with some clinicians structuring 8-12 week periods followed by a break