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In LLD, vitamin B1 deficiency can impair TCA cycle function, leading to disrupted energy metabolism in emotion-regulating brain regions such as the hippocampus and prefrontal cortex (37)
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10.1161/01.STR.0000050644.48393.D0 41

Ngo V, Duennwald ML

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Taken together these results provide further support that GLP-1RAs can alter the functioning of the GH/IGF-I axis