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Multi-center, randomized, placebo-controlled trials of epitalon, BPC-157, TB-500, and Semax in elderly populations could definitively establish efficacy and safety, potentially bringing these agents into mainstream gerontological practice ( 8 Conclusions Therapeutic peptides offer mechanistically diverse approaches to multiple hallmarks of aging, including metabolic dysfunction, telomere attrition, impaired tissue repair, and hormonal decline

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Cancers (Basel) 12, 3290

Indicated especially when neurological signs or severe anemia are present

Weight loss typically triggers adaptive reductions in metabolic rate, which can slow further weight reduction and promote regain

Within the immune landscape, leptin plays a central role in swaying the differentiation of CD4+ T cells towards a predominantly Th1-centric response (85)