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[,] Although VB12 deficiency has been well established to be a global health burden, our study result suggests the importance of exploring the clinical importance of high VB12 status, especially in the Chinese hypertensive population with significantly higher VB12 levels than the clinically suggested normal range. In addition, we found that the definition of high VB12 status varies significantly across different studies ascribed to the lack of a golden standard. [,,,] Further combined with the minor ratio of VB12 inadequacy status (VB12 deficiency and suboptimal deficiency) in recent studies, including this one, [,] this study suggests the need for an updated and systematic survey on VB12 levels

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