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[DOI] [PMC free article] [PubMed] [Google Scholar] Khoo N

However, maintaining consistent levels in the body may support long-term effectiveness
Consistent with decreased fasting glucose levels and improved insulin tolerance observed under chow, and to a lesser extent under HFD conditions (Figure 1, H and I, and Figure 2, J and L), GSH depletion significantly downregulated gluconeogenic enzymes G6pc and Pck1 in chow-fed mice, with no substantial change under HFD (Figure 3, A and B)

doi: 10.1146/annurev.pharmtox.39.1.67

Altogether, the major efforts in managing NF1-related neoplasms have been based on drugs targeting signaling transduction cascades such as RTK, RAS- RAFMEKERK and PI3K-AKTmTOR inhibitors

Its a recipe for disaster
