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The ladder is a set of stopping points
Aging, aging-associated hypertension and hypertension per se , either independently or collectively, impair endothelial function, leading to atherosclerosis, resulting in cardiovascular and cerebrovascular outcomes
Curr Opin Immunol (2009) 21(2):21523
E.MarcelisL
Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis
If 2.4 mg is not tolerated, the documented fallback is to hold at the highest tolerated step (commonly 1.7 mg) rather than push through severe GI effects
