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and thus negatively impact the normal physiological activities of host cells [97]

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Results ALOX12 expression is induced in DENV and ZIKV but not YFV infection To investigate the lipid mediator synthesis pathways in flavivirus infection, we focused on the key enzymes, including ALOX/COX (ALOX5/12/15 and COX2) and lipases (MGLL and cPLA2), as they are involved in both pro- and anti-inflammatory lipid mediator synthesis in cells [14,15,16, 18]