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Studies were done at the NBRL between 1968 to 1974 to document that patients with chronic hypovolemic anemia following traumatic injuries and patients with cardiopulmonary insufficiency had red blood cells with increased levels of RBC 2,3 DPG and RBC creatine

doi: 10.1007/s11064-022-03822-7 86 NehringHMeierjohannSFriedmann AngeliJP

This discovery opened a new avenue for free radical research, highlighting their role in signaling, initially for nitric oxide and later for other reactive species (Scandalios 2005)

Jusko WJ, Koup JR, Vance JW et al

[DOI] [PubMed] [Google Scholar] 24.Strle F, Maraspin V, Lotric-Furlan S, Rui-Sablji E, Cimperman J