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Such infections not only seriously damage the quality of life of patients, but also impose a heavy burden on the global healthcare system (Denning, 2024

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10.1084/jem.20172222 J

Its toxicity is linked to excessive Production of ROS, resulting in oxidative damage and inflammation in the inner ear

The OPTION-DM trial was a multicenter, randomized, crossover study comparing three monotherapy sequences (amitriptyline, duloxetine, pregabalin) against two dual-therapy sequences in patients who had failed one monotherapy [65]

Accepted at the Annual GI Symposium 2024
