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Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) expressed on epithelial cells interact with microbiota-derived pathogen-associated-molecular patterns (PAMPs) such as lipopolysaccharide (LPS) to activate myeloid differentiation factor 88 (MYD88)-dependent signaling

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While topical treatments can provide some visible improvement, addressing pigmentation from within often provides more sustainable and long-term results

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Genes that are involved in detoxifying compounds that we're exposed to from our food, like heterocyclic amines
