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Platelet activation, aggregation, and subsequent intra-arterial thrombosis are important steps in atherosclerotic thrombosis, and enhanced platelet reactivity is associated with the degree of terminal organ injury and poor prognosis ( 2+ release from intracellular stores ( in vivo can potentially lead to thrombosis, and within the physiological range of TMAO concentration observed in human and animal models, the effect of TMAO on platelet function is dose-dependent

Annu Rev Nutr

doi:10.1016/j.neuint.2012.04.008 [72] Benvenga S, Feldt-Rasmussen U, Bonofiglio D, et al