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Description
This presents a formulation challenge

Standard injectable dosing ranges from 2-5mg administered 2-3 times weekly
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doi: 10.1007/s12072-007-9007-4 122 XuLXuCYuCMiaoMZhangXZhuZet al

Most of the support for this method is anecdotal

Originator companies that have built their LOE forecasts assuming patent thicket durability comparable to AbbVies Humira success are likely over-estimating revenue tail durations

Of course, nothing was developed yet in the whole world at that time, but it was something new that everyone was just dabbing their feet around