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High abdominal pressure at 25, 30, 40, or 50 mmHg was maintained until sacrifice at 60 min (25 mmHg), 30 min (30 mmHg, 40 mmHg), or 15 min (50 mmHg)

Antioxidants Considering the role of oxidative stress and antioxidants in the pathogenesis of migraine attacks, antioxidants could alleviate the migraine attacks
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The results of a sequential supplementation trial in 53 men and women indicated that after optimization of folate status with folic acid supplements, vitamin B 12 became the major determinant of plasma homocysteine levels (30)

Glucose may be the primary energy source in thick ascending limb, even though lactate, fatty acids, and ketone bodies may also contribute
Mitochondrial dysfunction enhances ROS generation via the NADPH oxidase pathway (135)

Zhang et al., 2015), as well as neuronal health and survival (Ohta et al., 2003, 2010
