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Supporting this cofactor-binding mode, mutations of residues that interact with NADP have been shown by previous enzymological studies to either decrease or abolish the catalytic activity of SRD5A2 (Extended Data Fig
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In addition to analyzing the ADME toxicity of the selected natural products using the Swiss ADME server, ADMET SAR was also used to evaluate the drug-like properties of several natural products (Maurya et al
