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doi: 10.1007/s00299-023-03112-8

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Second, to achieve precise clinical diagnosis of UC, more reasonable diagnostic criteria, such as noninvasive serological tests, gut microbiota testing, and detection of specific metabolites, should be developed and applied in clinical practice

3.2.3 Cytosolic mtDNA and the cGAS-STING pathway mtDNA is particularly vulnerable to oxidative damage due to its lack of histone protection and proximity to ROS generation sites (Wang et al., 2025a

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Hammond et al., 2001)