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K sum = K sp (CaCO 2 )/ K a (HCO 3 ) = 3.3610 -9 / 4.710 -11 = 71.5

Age groups ranged from neonates to adults, complicating direct comparisons

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Both reaction rates and protein abundances (inputs) were varied using Latin hypercube sampling (LHS), and partial rank correlation coefficients (PRCCs) 36 were calculated and significant PRCCs reported for pAkt and pERK (outputs) at 120 min that represents steady state (Fig

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