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HDAC5 inhibits NRF2-dependent antioxidant gene expression and plays an important role in regulating redox homeostasis in cardiomyocytes [65]

The NNMT inhibitor works bottom-up at the cellular level by addressing the enzymatic dysfunction within adipocytes themselves

During the reaction, Universal GSH in the sample or standard competes with a fixed amount of Universal GSH on the solid phase supporter for sites on the Biotinylated Detection Ab specific to Universal GSH

-synuclein and astrocytes: tracing the pathways from homeostasis to neurodegeneration in Lewy body disease

(1994) Esters

Abbreviations 4-PB: 4-phenylbutyrate A1AT: Alpha 1-antitrypsin ABC: ATP-binding cassette AFP: Alpha-fetoprotein ASBT: Apical sodium dependent bile acid transporter BAs: Bile acids BSEP: Bile salt export pump CA: Cholic acid CDCD: Chenodeoxycholic acid CYP: Cytochrome P450 DCA: Deoxycholic acid DCDC2: Doublecortin domain containing 2 FGFR4: fibroblast growth factor receptor 4 FXR: farnesoid X receptor G(T)CA: Glyco- or tauro-cholic acid G(T)CDCA: Glyco- or tauro-chenodeoxy cholic acid GGT: Gamma glutamyl transpeptidase HCC: Hepatocellular carcinoma IEBAM: Inborn error of bile acid metabolism LCA: Lithocholic acid MDR2/3: Multidrug resistance protein 2/3 MRP2/3/4: Multidrug resistance-associated protein 2/3/4 MYO5B: Myosin VB NASH: Nonalcoholic steatohepatitis NH: Neonatal hepatitis NICCD: Neonatal cholestasis caused by citrin deficiency NTCP: Sodium/taurocholate co-transporting polypeptide OATP1B1/3: Organic-anion-transporting polypeptide 1B1 and 1B3 OST/: Organic solute transporter-/ PC: Phosphatidylcholine PFIC: Progressive familial intrahepatic cholestasis PS: Phosphatidylserine RXR: Retinoid X receptor SERPINA1: Serpin family A member 1 SHP: Small heterodimer partner TFAM: Mitochondrial transcription factor A TGR5: Takeda G protein-coupled receptor 5 (G protein-coupled bile acid receptor 1 , GPBAR1) TJP2: Tight junction protein 2 UDCA: Ursodeoxycholic acid UGT1A1: UDP-glucuronosyltransferase 1A1 References Esteller A