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As the soft -carbon atom of acrolein forms an adduct with a soft nucleophile target on a protein (Michael addition), the harder carbonyl carbon atom of acrolein can potentially attack a hard nucleophile site (e.g., Lys) on a separate protein (1,2-addition)

Notably, tumor angiogenesis plays a crucial role in the occurrence of drug resistance in breast cancer

Acknowledgments The author would like to thank all the authors for their contributions to this article

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Beta-HCG is produced by trophoblastic cells of the placenta and promotes angiogenesis, showing higher values in preeclampsia, as well as high levels of MDA