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PHGDH inhibits ferroptosis and promotes malignant progression by upregulating SLC7A11 in bladder cancer
Research should focus on understanding the underlying mechanisms and identifying which individuals are most likely to benefit
Briefly, when either caspase 8 or fas-associated via death domain (FADD) is depleted or the function is inhibited, TNF can induce caspase 8 independent necrosis through activating RIPK1 (receptor interacting serine/threonine kinase 1) [94]
Cox et al., 2020)
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