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It has been shown that KPT-9274 can promote apoptosis and induce DNA damage in vitro, 312 and significantly reduces tumor proliferation and survival in xenograft models in different tumors, such as pancreatic cancer, 309 pancreatic neuroendocrine tumors, 313 triple-negative breast cancer 311 , and leukemia

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In addition, we were able to resolve the interaction sites at the single amino acid level

AKF-PD alleviates diabetic nephropathy via blocking the RAGE/AGEs/NOX and PKC/NOX Pathways

Cells were loaded with 20 M ThiolTracker Violet glutathione detection reagent and 100 nM SYTO 16 Green Fluorescent Nucleic Acid Stain (Invitrogen, catalog # S7578) and imaged within the hypoxic environment using an LS620 microscope (Etaluma, Carlsbad, CA, USA) fitted with a 20 objective at 0, 30 min, and 6 h at 1% O 2

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