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Hedrick et al., 2006)

doi: 10.2147/IJN.S258791 [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted] 143.Rajput A, Bariya A, Allam A, Othman S, Butani SB

Pharmacokinetic effects of isavuconazole coadministration with the cytochrome P450 enzyme substrates bupropion, repaglinide, caffeine, dextromethorphan, and methadone in healthy subjects
Human fibroblasts with mutations in COL5A1 and COL3A1 genes do not organize collagens and fibronectin in the extracellular matrix, down-regulate alpha2beta1 integrin, and recruit alphavbeta3 instead of alpha5beta1 integrin

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Beyond commercial feasibility, manufacturing-derived impurities can independently provoke adverse immune responses
