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Bioavailability of quercetin is an important issue and a serious obstacle for its use in AD treatment

Cytokine Growth Factor Rev 25:4555

An example is treatment with the toxic bile acid lithocholic acid, which caused initial GCLC induction, followed later by suppression at the transcriptional level in hepatocytes [90]

Sperandio S, Poksay K, de Belle I, Lafuente MJ, Liu B, Nasir J, et al

The absence of suitable human models has also hindered mechanistic studies of -cell identity loss in T2D, a limitation now addressed by human embryonic stem cell (hESC)-derived islets (SC-islets), which are increasingly used to investigate human -cell development and islet pathology in diabetes

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