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Surprisingly, acute ELAM increased uptake of ADP through the ANT in isolated mitochondria but did not increase ATP synthesis

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P53 phosphorylation at Ser15 was confirmed to enhance the affinity for both FOXO4 and FOXO4-DRI, providing a structural explanation for FOXO4-DRIs preferential engagement with the hyperphosphorylated p53 that characterises senescent cells

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9,36 Consequently, this induces a pseudo-first-pass effect that interferes with drug absorption 37 and negatively affects the pharmacokinetic and pharmacodynamic profiles of the drugs

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