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It functions as a critical component of the cellular antioxidant defense system, participating in detoxification reactions, protein folding, and redox homeostasis

Within the TME, immunosuppressive cells, such as myeloid DCs and CD4+ Th1- and Th2-type T cells, have been positively associated with the expression of GPX3 (100)

MT-3 acts as an inhibitor of adipocyte differentiation by suppressing adipogenic transcription factors, including C/EBP family members and PPAR, and downregulating PPARs transcriptional activity, with its regulatory impact linked to ROS scavenging [63]