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Add 1 mL of bacteriostatic water to produce a 2 mg/mL (2,000 mcg/mL) concentration

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As a result, folate deficiency can lead to many neuropsychiatric manifestations, such as depression, alterations in neurotransmitter function, DNA damage, as well as being associated with the development of autism spectrum disorders in children, neural tube irregularity and brain development defects (, , , , , , , )

Pathogenic mutations in MTHFR gene have been associated with severe MTHFR deficiency

Medical Review Status Last reviewed: June 2026 | Next review: December 2026 Written by Dr