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Remarkably, modifications neutralizing the charge on NACs carboxyl group, such as amidation or esterification, have been shown to significantly enhance its cellular uptake, as previously reported [25,26]
Nox inhibitors & therapies: rational design of peptidic and small molecule inhibitors
10.1046/j.1365-2362.2000.00736.x [DOI] [PubMed] [Google Scholar] Dias V., Junn E., Mouradian M
Genome Biology 15, R27
How pronounced these patterns appear can vary between athletes
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