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Rotenone, paraquat, and Parkinson's disease
Multi-omics integration revealed a high-inflammation, high-oxidation, low-metabolism triad, which is mainly regulated by the Stat1-(2-carboxypropyl)-Cysteamine-C3 interaction axis
Our studies with the Broad Institute's Connectivity Map revealed its ability to regulate a large number of human genes including those that are involved in nervous system physiology, development, and maintenance
Free radicals are unstable molecules generated by everyday exposure to pollution, UV radiation, processed foods, chronic stress, and normal metabolic processes
The quantitative experiments were all repeated three times
Belkaid and Hand, 2014
