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An important role of Nrf2-ARE pathway in the cellular defense mechanism

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Finally, prospects for ferroptosis-based interventions and future directions point to several promising treatment avenues, including regulating iron homeostasis via chelators or TfR1/FPN modulation, using antioxidants and lipid peroxidation inhibitors to target GPX4 and ACSL4, or employing gene therapies and stem cell/exosome approaches to combat ferroptosis

In this regard, maternal stress appears to play a pivotal role in initiating the immune response that may induce neurodevelopmental changes, contributing to the onset of neuropsychiatric disorders such as ASD [13,15,16]