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Structure of oxidized GPX4 U46C-K48A is modeled based on oxidized GPX4 U46C-K48A crystal structure reported in this work

It is commonly accepted that oxidative stress induced by excess ROS/RNS levels is detrimental to biological functions and is involved in the development of many pathological conditions, such as cardiovascular diseases, neurodegenerative diseases, aging, and cancer (30, 90, 106)

Biochemical Pharmacology (NLM) .Read source (2021)

doi: 10.5607/en.2015.24.4.257 124 YuT

This enzyme plays a crucial role in a process called methylation, which is important for various bodily functions including DNA synthesis, neurotransmitter production, and detoxification