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For mice, prominent dose-related changes included bronchiolization of alveolar walls (alveolar epithelium changed from a simple squamous to a tall columnar epithelium resembling that of the terminal bronchioles)

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10.1016/j.jmb.2012.04.029 Pearl EJ, Bokor AA, Butler MI, Poulter RT, Wilbanks SM: Preceding hydrophobic and beta-branched amino acids attenuate splicing by the CnePRP8 intein

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