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The latency required for negative inotropy in isolated rat hearts is notably reduced relative to the equivalent lower (2060 min for negative inotropy) and higher doses (515 min) that increase papillary muscle contractility (Hara et al., 1996, 1997

doi: 10.1194/jlr.M042572

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Furthermore, miR-122 silencing in high-fat-fed mice reduced hepatic steatosis, with a decrease in cholesterol synthesis and stimulation of FAO 85
