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The deficiency of Nrf2 in Nrf2 knockout (KO) mice attenuated the chondroprotective effect of metformin on OA development, further affirming the core position of Nrf2 signaling during metformin fights illness as an antioxidant

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Palmitoylethanolamide (PEA) is a naturally occurring fatty acid studied to show neuroprotective, anti-inflammatory, antihistamine/mast cell stabilizing, and analgesic properties