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Pregnancy and Breastfeeding: Pregnant and breastfeeding women have increased vitamin B12 requirements to support the growth and development of the fetus or infant

Endothelial dysfunction has been demonstrated in vivo (306, 311), in the large vessels of ME/CFS patients (307, 311) through flow-mediated dilation (FMD) and in the microcirculation through post-occlusive reactive hyperaemia

B12 is only found in animal products (meat, eggs, shellfish, dairy), making deficiency especially common among vegans and vegetarians

Document daily dose, injection site, and any observations to maintain consistency

PMID: 26236730 Pickart L, Margolina A
