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Disruptions in any of these systems can lead to the accumulation of misfolded, damaged, or aggregated mitochondrial proteins, ultimately causing cellular dysfunction and contributing to diseases such as mitochondrial myopathies and cardiomyopathies 10,11,12

[DOI] [PMC free article] [PubMed] [Google Scholar] Kranzler HR, Armeli S, Tennen H (2012) Post-treatment outcomes in a double-blind, randomized trial of sertraline for alcohol dependence

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