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While safe at therapeutic doses of up to 4 g per day for adults, APAP overdoses, either accidental or intentional, are one of the leading causes of acute liver failure in the United States [33]

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On a herbicide molecule, these groups can serve as leaving groups when reacted with the nucleophilic glutathione anion (GS - )

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iNOS is an important, but not the only possible source of NO in APAP liver toxicity

Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia