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4.2.2 Targeting Gln-related metabolic enzymes In addition to Gln uptake inhibitors, enzymes involved in Gln metabolism also play a crucial role in tumor progression
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Discontinuation rates due to adverse events were reported as low and single-digit across both REDEFINE 1 and 2, which Novo Nordisk highlighted as a positive tolerability signal given the drugs dual-mechanism approach

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Circulation (2021) 144:47184
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Fertil Steril 1997;68:585-96
