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Peak blood concentrations of trichloroethylene after exposure to trichloroethylene vapors are achieved in 1-2 hours in mice exposed at 100-750 parts per million (ppm), in 4-6 hours in rats exposed at 500-600 ppm, and in 8-12 hours in humans exposed at 100 ppm (Prout et al

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Furthermore, tumor core regions display low glutamine levels compared to the periphery, and this regional glutamine deficiency in tumors promotes de-differentiation through the inhibition of histone demethylation [40,43]

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