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Drawing from this parallel, we hypothesize that the premature death observed in our LMNA (W520G) fish may indeed reflect the pathogenicity of the protein variant

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Multiple transcription factors, including Hoxa1 and Bcl-2 (B-cell lymphoma protein 2), can affect the transcription of possibly hazardous genes in the open and uncondensed chromatin, which increase apoptosis regulation while decreasing morphogenesis (essential for differentiation of organ) and cellular proliferation, respectively (Ornoy, 2009)
