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Drug-eluting microspheres have been widely used in the treatment of hepatocellular carcinoma for the simultaneous effects of embolization of blood vessels supplying tumors and sustained release of chemotherapeutic agents (137)
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Nephrotoxicity VPA causes oxidative stress, mitochondrial deficiencies, carnitine shortage, fibrosis, and inflammation in mice renal tissue, according to experimental and clinical investigations (Hamed, 2017)

Markuss team reported that the myeloid-biased output of HSCs was mediated by interleukin-1 (IL-1) signaling in a mouse model
