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Figure 2 2.2.1 CD8+ T cells CD8+ T cells, key immune effector cells in the TME, are involved in tumor clearance, as well as in responding to viral infections and other pathological conditions ( in vitro studies have demonstrated that glutamine deprivation can promote the differentiation of memory CD8+ T cells, facilitating the development of long-lasting immune memory ( in vivo inhibition of glutamine metabolism helps prevent CD8+ T cell exhaustion, sustaining their long-term effector functions ( 2.2.2 CD4+ T cells Upon antigenic stimulation, CD4+ T cells undergo metabolic reprogramming, activating pathways critical for their proliferation and differentiation ( via epigenetic mechanisms

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The clinical experiment was performed using PS with topical application on human skin in vivo , just as Kim's study (80)

Furthermore, advanced research into ferroptosis mechanisms in CHD may identify novel targets and strategies for CHD prevention and treatment, potentially mitigating myocardial injury by inhibiting ferroptosis-related signaling pathways or enhancing antioxidant capacity, ultimately improving cardiac function and quality of life for CHD patients
