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Increased NEFAs in cells compete with glucose for substrate oxidation, thus resulting in the inhibition of pyruvate dehydrogenase, phosphofructokinase, and hexokinase II [8]

None are randomized controlled trials

If the injection is placed close to a nerve or in an area with significant scar tissue, it may cause additional irritation

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Treatment with 5-amino-1mq upregulates proliferationrelated genes (Ki67, PCNA), promotes cell cycle progression, and improves cell fusion efficiency to form more multinucleated myotubes, achieving functional levels similar to those of young mice.Additionally, 5-amino-1mq inhibits muscle stem cell apoptosis, reduces oxidative stress damage, and maintains stemness

36 The MRI imaging study 37 reveals that although the intended plane of injection was the subcutaneous compartment, nearly half of the HA filler was delivered into the muscle, an area at higher risk for severe complications such as vascular access and filler embolization