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In the ACTEMRA-IV monotherapy clinical study, the rate of serious infections was 3.6 per 100 patient-years in the ACTEMRA group and 1.5 per 100 patient-years in the methotrexate group

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Many of the identified risk loci are shared with Rheumatoid Arthritis and Systemic Lupus Erythematous, including alleles located in MHC , STAT4 , CD247 , and IRF5 loci (Radstake et al., 2010