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Dysregulated endosomal trafficking contributes to type I interferon activation via signalling through Toll-like receptors, aberrant autoantigen presentation, and altered expression of metabolite transporters in immune cells and target organs

Gene-level modulation: Pickart & Margolina 2018 documented activity across ~4,000 human genes, with fibroblast expression patterns shifting closer to younger cells

, Therefore, we used an RNAscope probe against Slc7a11 and revealed its expression within TLS (Figure 3B)

131 , e152067 (2021)

In Japan, population projections indicate that the number of people aged 70 and over will exceed 25% by 2040, resulting in a shrinking workforce, which is recognized as a serious problem [913]