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The metabolic changes continue in the liver where O-methylated and/or glucuronated conjugates originate as the result of glucuronidation and sulfation of the hydroxyl groups and O-methylation of the catechol groups

NAFLD could be considered an hepatic manifestation of metabolic syndrome, given the strong association with obesity, type 2 diabetes, hypertension and dyslipidaemia (3)

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Lastly, topical treatment of tomato Cu,Zn-SOD [297] or intramuscular injection of bovine Cu,Zn-SOD [298] near the injured areas has been proven in clinical investigations to reduce radiotherapy-induced fibrotic areas for a number of days