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Another essential difference that may explain the variance between the studies is the selection of the teeth subject to examination

Biochemistry 20, 27772782

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We combined data from all trials to estimate the pooled risk ratio (RR) with 95% confidence intervals (CIs) for mortality, infectious complications, VAP and overall weighted mean difference (WMD) with 95% CIs for LOS data

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Some studies suggest the peptide may remain viable beyond that window, but 28 days is the conservative standard most protocols follow