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Because the ADC strands are design to preferentially hybridize with cellular miRNAs, the encapsulated siRNAs are released from core/shell nanoparticles into the nucleoplasm owing to strand displacement reactions (step V) and enter the RNAi pathway, knocking-down the expression of tumor-promoting genes

Parakh et al., 2018b)

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Additionally, the endothelial cells of the choriocapillaris are connected by tight junctions and, along with astroglial end-feet, pericytes, and Mller glial cells, form the inner blood-retinal barrier (iBRB)