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N Engl J Med.2020;382(13):1270-1272

DDA mass spectra were analyzed with Proteome Discoverer (version 3.0.1.27) and searched by using Sequest HT + INFERYS rescoring against the human SwissProt database (version 2023-06-28) plus a custom KRAS G12C database with dynamic methionine oxidation and static cysteine carbamidomethyl modifications

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Volume (mL) = Mass (mg) / Target Concentration (mg/mL)

Mean values are based on one kitten per replicate and six replicates per treatment