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Evaluating the effects of amantadin, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis--result of a pilot randomized, blind study

Synergistic effects: SAMe may also exhibit synergistic effects when combined with other treatments, such as painkillers or antidepressants, which can enhance its therapeutic potential in FM management [69, 70]

Uzun, N., Sarikaya, S., Uluduz, D., and Aydin, A

[1] [4] Other possible adverse effects include skin rash, muscle weakness, or seizures in people with epilepsy

It also has a protective effect on neuroinflammation [124]

A randomizedcontrolled trial of dehydroepiandrosterone in postmenopausal women withfibromyalgia