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Preclinical development of near-infrared-labeled CD38-targeted daratumumab for optical imaging of CD38 in multiple myeloma

Intramuscular (IM) hydroxocobalamin injections bypass the intrinsic factor-mediated absorption mechanism, delivering the entire dose directly into circulation

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Also since most of serine inhibiting phosphorylation occurs in IRS-1, it renders IGF-1R a rescue pathway to reinstitute insulin sensitivity
