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This is especially important for maintaining body temperature in cold environments (Yamakawa et al

This results in a deficiency of MTHF, which in turn leads to a deficiency of SAM

Yang H, Xie Y, Yang D, Ren D

In the future, HLO-based screening model accounting for diverse host genetics and other clinical factors can be developed based on this study ( FIGURE 4 3.3 Prevention of AILI DILI has become a significant global health burden due to its high morbidity and mortality ( The foundation of preventing DILI is vigilance during preclinical drug development and clinical trials

doi: 10.1007/s12020-022-03107-7 117

Finally, supplementing NaGYY, the sodium salt of GYY4137, a slow-releasing H 2 S donor, restored sulfhydration and ameliorated motor and cognitive deficits in the 3xTg-AD mice (Giovinazzo et al., Figure 2 Therapeutic Avenues Analysis of clinical trials conducted so far, reveal a preference for non-amyloid targets, which include therapeutics targeting inflammation, synapse and neuronal protection, vascular factors, neurogenesis, and epigenetic modifications (Cummings et al., 2 S regulates a wide array of neuroprotective processes, therapies, and interventions involving either the use of H 2 S delivering drugs or agents which stimulate its production are gaining importance